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TLR4 induced miR-147 expression requires both MyD88 and TRIF. (A–C) Peritoneal macrophages were isolated from WT, MyD88−/−, and TRIF−/− mice. The cells were treated with 1 μg/mL PAM3CSK4 (A), 5 μg/mL poly(I:C) (B), or 1 μg/mL LPS (C) for 0 or 6 h. Real-time PCR was performed to determine the levels of miR-147. Values are presented as mean ± SD from triplicate wells. **, P < 0.01 compared to MyD88−/− or TRIF−/− macrophages.
