Table 2.
Relative rates of fractures in cases with primary hyperparathyroidism and matched controls. Before surgery there were 9229.4 observation years among cases and 27 670.0 among controls; after surgery there were 3631.5 observation years among cases and 12 037.7 among controls
| Fracture site (ICD-8 and ICD-10 codes) | No of fractures before surgery*
|
Relative rate (95% CI) | No of fractures after surgery*
|
Relative rate (95% CI) | P value † | ||
|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | ||||
| Skull, face, and jaw (80099, 80100-80109, 80210-80299, 80399, S020-S029) | 2 (8) | 7 (7) | 0.9 (0.2 to 4.1) | 0 (0) | 1 (1) | 0 | — |
| Vertebrae (80500-80599, S120-S129, S220-S221, S320-S328) | 7 (11) | 6 (9) | 3.5 (1.3 to 9.7)‡ | 3 (3) | 13 (15) | 0.8 (0.2 to 2.7) | 0.065 |
| Upper extremity and clavicles (81099, 81199, 81200-S81299, S420-S429) | 6 (7) | 15 (25) | 1.2 (0.5 to 3.1) | 6 (9) | 29 (66) | 0.7 (0.3 to 1.6) | 0.39 |
| Forearm (81300-81399, S520-S529) | 19 (31) | 30 (48) | 1.9 (1.1 to 3.3)‡ | 11 (26) | 50 (100) | 0.7 (0.4 to 1.4) | 0.029 |
| Distal forearm (81320-81329, S525, S526) | 11 (18) | 24 (40) | 1.4 (0.7 to 2.8) | 10 (22) | 46 (89) | 0.7 (0.4 to 1.4) | 0.20 |
| Rest of forearm (81300-81319, S520-S529) | 8 (13) | 6 (8) | 4.0 (1.5 to 10.6)‡ | 1 (4) | 4 (11) | 0.8 (0.1 to 7.4) | 0.20 |
| Hand (81400-81409, 81500-81509, 81600-81604, 81899, S620-S628) | 6 (7) | 8 (11) | 2.2 (0.8 to 6.3) | 3 (5) | 19 (22) | 0.5 (0.2 to 1.7) | 0.07 |
| Femur (82000-82009, 82109-82199, S720-S729) | 16 (27) | 33 (76) | 1.5 (0.8 to 2.6) | 24 (51) | 63 (145) | 1.3 (0.8 to 2.0) | 0.72 |
| Femoral neck (82000, 82001, S720, S721) | 14 (24) | 29 (64) | 1.4 (0.8 to 2.7) | 21 (42) | 58 (125) | 1.2 (0.7 to 2.0) | 0.65 |
| Lower leg (82300-82399, 82400-82409, S821-S829) | 19 (36) | 27 (37) | 2.1 (1.2 to 3.7)‡ | 11 (16) | 22 (40) | 1.7 (0.8 to 3.4) | 0.61 |
| Distal lower leg and ankle (82329, 82400-82409, S821, S827) | 16 (31) | 21 (24) | 2.3 (1.2 to 4.3)‡ | 5 (9) | 15 (29) | 1.1 (0.4 to 3.0) | 0.23 |
| Rest of lower leg (82300-82399, S824-S829) | 3 (5) | 6 (9) | 1.5 (0.4 to 5.9) | 6 (7) | 7 (11) | 2.8 (1.0 to 8.1) | 0.47 |
| Feet (82500-82509, 82600-82609, 82799, S920-S929) | 6 (7) | 12 (13) | 1.5 (0.6 to 4.0) | 6 (9) | 11 (16) | 1.8 (0.7 to 4.8) | 0.79 |
| Total (all of above) | 81 (134) | 138 (226) | 1.8 (1.3 to 2.3)‡ | 64 (119) | 208 (405) | 1.0 (0.8 to 1.3) | 0.006 |
*
Number of subjects with at least one fracture; number in parentheses is total number of discharges with fracture.
†
Comparison of relative rate before and after surgery. If P<0.05 surgery significantly influenced the risk of fractures in cases compared with controls (Poisson regression).
‡
P<0.05, Mantel-Haenszel χ2.