Table 1.
Selected characteristics of the subjects and expression of selected genes
| Obese T2DM (15 men, 15 women) | Obese controls (9 men, 9 women) | |
|---|---|---|
| Anthropometric and metabolic characteristics | ||
| Age (y) | 59 ± 9 | 55 ± 9 |
| Weight (kg) | 96 ± 10 | 97 ± 14 |
| BMI (kg/m2) | 33.5 ± 2.5 | 32.1 ± 1.6 |
| Body fat (%) | 36 ± 7 | 37 ± 8 |
| Ratio VAT/SAT | 0.96 ± 0.58 | 0.83 ± 0.55 |
| Adipocyte size (μL) | 0.92 ± 0.28a | 0.75 ± 0.17b |
| Fasting glucose (mg/dL) | 146.2 ± 25.9a | 99.9 ± 7.7c |
| Fasting insulin (μU/ml)d | 12.5 ± 0.2 (5.5,25.1)a | 9.4 ± 0.2 (3.8,40.5)b |
| HbA1c (%) | 6.8 ± 1.0a | 5.3 ± 0.8c |
| Glucose disposal (mg/min/kg FFM) | 5.5 ± 2.0a | 10.0 ± 3.6c |
| Gene expression in stromovascular cells (A.U.) | ||
| aP2 | 0.35 ± 0.16a | 0.58 ± 0.27b |
| JNK-1 | 1.20 ± 0.68 | 1.09 ± 0.73 |
| MIFd | 1.5 ± 0.2 (0.7,3.7) | 1.3 ± 0.2 (0.7,3.7) |
| MMP2d | 1.7 ± 0.2 (0.7,4.3)a | 1.3 ± 0.2 (0.4,3.2)b |
| IL-6d | 0.2 ± 0.4 (0.1,1.1) | 0.2 ± 0.5 (0.1,2.1) |
| CD68d | 2.3 ± 0.2 (0.8,6.0) | 2.6 ± 0.2 (1.1,9.2) |
| MCP1d | 1.3 ± 0.3 (0.3,4.2) | 1.4 ± 0.3 (0.6,8.9) |
| 11β-HSD1 | 1.71 ± 0.51 | 1.79 ± 0.83 |
| IKKβd | 1.2 ± 0.2 (0.5,2.7) | 1.0 ± 0.2 (0.4,3.2) |
| MIP1A | 2.07 ± 1.74 | 1.94 ± 1.41 |
| TNFαd | 4.8 ± 0.8 (0.002,35.5) | 5.2 ± 0.7 (0.1,48.1) |
| Cyclophilin B | 2.59 ± 1.08 | 2.36 ± 1.45 |
| Gene expression in adipose tissue (A.U.) | ||
| Pref-1 | 1.35 ± 1.23 | 1.37 ± 0.88 |
Data are means ± SD or geometric means ± SD (range) as appropriate;
a–b
p < 0.05;
a–c
p < 0.0001;
d
log transformed; A.U., arbitrary units.