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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Mol Pharmacol. 2008 Sep 18;74(6):1576–1586. doi: 10.1124/mol.108.050633

Fig. 1.

Fig. 1

Quinolines alter the intracellular trafficking of tyrosinase (Tyr) and tyrosinase-related protein 1 (Tyrp1). A, alterations of the subcellular localization of Tyr and Tyrp1 by quinolines. Immunofluorescence confocal microscopy images are shown with immunostaining of Tyr (green) and Tyrp1 (red). The colocalization of tyrosinase with tyrosinase-related protein 1 is indicated in yellow in the merged image. Scale bars, 5 µm. B, tyrosinase traffics beyond the TGN in melan-a cells treated with quinolines. Immunofluorescence confocal microscopy images are shown with immunostaining of Tyr (green) and TGN38 (red). The colocalization of tyrosinase with TGN38 is indicated as yellow in the merged image. Scale bars, 5 µm.