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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Mol Pharmacol. 2008 Sep 18;74(6):1576–1586. doi: 10.1124/mol.108.050633

Fig. 3.

Fig. 3

Chloroquine and quinine salicylate decrease melanin accumulation of Asian human skin equivalent (MEL-A). MEL-A were treated with 0.5 mM chloroquine, 4.0 mM quinine salicylate, 3 mg/ml arbutin, or controls (either water or 30:70 water/PEG) for 13 or 16 days. Representative data from multiple experiments are presented. A, changes in melanin content of MEL-A. Data are presented as the percentage of control, and each column represents the mean ± S.D. of multiple experiments. B, phase-contrast microscopic images of MEL-A. C, immunohistochemical appearances of MEL-A after Fontana-Masson staining to emphasize melanin content.