Table 5.

Main functions identified using IPA (all with P value <0.0001)

Top Canonical Pathways	Ratio
Hepatic fibrosis/hepatic stellate cell activation	10/135 (0.074)
Complement system	6/36 (0.167)
Acute phase response signaling	11/178 (0.062)
HIF1α signaling	8/105 (0.076)
Leukocyte extravasation signaling	10/195 (0.051)

Top Biological Functions	Molecules
Diseases and disorders
Cancer	93
Inflammatory response	58
Reproductive system disease	48
Renal and urological disease	26
Hematological disease	49
Molecular and cellular functions
Cellular movement	52
Antigen presentation	53
Cell-to-cell signaling and interaction	51
Cellular growth and proliferation	75
Cell death	70
Physiological system development and function
Tissue morphology	57
Hematological system development and function	64
Immune cell trafficking	40
Cell-mediated immune response	70
Humoral immune response	55

IPA, Ingenuity Pathway Analysis.