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. Author manuscript; available in PMC: 2009 Sep 21.
Published in final edited form as: Org Lett. 2008 Feb 20;10(6):1231–1234. doi: 10.1021/ol800086s

Table 1.

Alkyne Scope

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entry products 6:7a yield (%) ee (% of 6)b ee (% of 7)b
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1 6a (Ar = Ph) 7a 1:8 76 84 90
2 6b (Ar = 4-MeOC6H4) 7b < 1:20 80 - 91
3 6c (Ar = 4-BrC6H4) 7c 1:3 77 82 88d
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4 6dc 7dc 1:9 64 - 91
a

Product selectivity determined by 1H NMR of the unpurified mixture.

b

Determined by HPLC using a chiral stationary phase.

c

Alkyne and product E:Z = 97:3.

d

Absolute stereochemistry determined by X-ray.