Table 1. Ventricular parameters in wild type and ob/ob mice hearts subjected to TAC.

Functional analysis obtained from M-mode echocardiograms. Measurement of the left ventricle, systolic (ESD) and diastolic (EDD) dimensions, intraventricular septum, wall thickness in each group revealed the development of left ventricular hypertrophy as determined by left ventricular mass (Lvmass) and posterior wall thickness (PWT). Values are means ± s.e.m. Sham vs TAC group

	C57BL/6J		ob/ob
	Sham (n = 8)	TAC (n = 9)	Sham (n = 6)	TAC (n = 6)
Body weight (g)	28.4 ±0.4	29.3 ±0.5	46.2 ±0.7	49.1 ±0.3
Heart rate (HR, beats/min)	549 ±17	560 ±26	535 ±11	545 ±14
Left Ventricular Mass (Lvmass, mg)	71 ±7	111 ±4 ‡	85 ±3	139 ±8 ‡ #
Septal wall thickness diastole (mm)	0.81 ±0.05	0.99 ±0.05	0.73 ±0.02	1.20 ±0.07 ‡
Septal wall thickness systole (mm)	1.55 ±0.01	1.61 ±0.04	1.35 ±0.04	1.82 ±0.02 ‡
Posterior wall thickness diastole (mm)	0.75 ±0.03	0.95 ±0.05 ‡	0.73 ±0.02	1.09 ±0.01 ‡
LVEDD, (mm)	3.20 ±0.06	3.10 ±0.04	3.55 ±0.04	3.46 ±0.06
LVESD, (mm)	1.56 ±0.04	1.61 ±0.03	1.75 ±0.01	1.56 ±0.01
Fractional Shortening (%)	53 ±3	48 ±5	50 ±2	54 ±3

^*P values < 0.05. ob/ob vs. C57BL/6J subjected to TAC

^#P values < 0.01 were considered statistically significant.