Table 5.
Patients who met clinically relevant criteria for cardiovascular-related measurements by daily dose at final treatment visit
| Measurement, n (%) |
Daily dosage of OROS methylphenidate (N = 370) |
||||
|---|---|---|---|---|---|
| 18 mg | 36 mg | 54 mg | 72 mg | 90 mg | |
| n = 21 | n = 82 | n = 110 | n = 65 | n = 32 | |
| Systolic blood pressure (≥ 140 mmHg) | 2 (9.5) | 13 (15.9) | 20 (18.2) | 14 (21.5) | 11 (34.4) |
| Diastolic blood pressure (≥ 90 mmHg) | 6 (28.6) | 23 (28.0) | 25 (22.7) | 22 (33.8) | 12 (37.5) |
| Pulse (≥ 90 beats per minute) | 7 (33.3) | 29 (35.4) | 37 (33.6) | 32 (49.2) | 16 (50.0) |
Note: Measured while patient standing; n = number of patients who met criteria; percentage denominator is total number of patients with the same dosage at final treatment week. Excludes patients who took no drug on the visit day for the treatment week or did not attend the visit day (see Figure 1).