Table 3.
Compound | IC50 (μM) FPA | Kd (μM) ITC | |||
---|---|---|---|---|---|
IC50 | Bcl-XL | Bcl-2 | Mcl-1 | Bfl-1 | Bcl-XL |
2 | 3.7 | 4.3 | 2.6 | >10 | 1.7 |
12e | 3.5 | 0.48 | 0.83 | 5.0 | 0.41 |
8m | 1.1 | 0.71 | 0.78 | 2.0 | 0.85 |
8n | 0.80 | 0.15 | 0.30 | 0.55 | ND |
8p | 6.3 | 4.4 | 3.2 | NDa* | ND |
8q | 0.93 | 0.67 | 0.59 | 1.3 | 0.12 |
8j | 0.8 | 0.70 | 1.1 | ND | ND |
8k | 0.27 | 0.49 | 0.23 | 0.40 | 0.11 |
8r | 0.76 | 0.32 | 0.28 | 0.73 | 0.11 |
8s | 0.85 | 0.70 | 0.35 | 0.67 | ND |
ND = Not determined