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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Bioorg Med Chem. 2009 May 8;17(14):5318–5324. doi: 10.1016/j.bmc.2009.05.008

Table 4. Inhibition data from an in vitro HIV-1 IN assay.

graphic file with name nihms116460f7.jpg
No. R IC50(μM) IC50(μM)
3′-P ST 3′-P ST
(S)-Chirality (R)-Chirality
k graphic file with name nihms116460t16.jpg 128 ±11 1.8 ± 0.3 290 ± 18 12 ± 2
l graphic file with name nihms116460t17.jpg 111 ± 13 10 ± 1 > 333 81 ± 2