Figure 6.
Oct-1 motif at -10.2 kb confers transcriptional activation to a heterologous thymidine kinase (TK) promoter. HepG2 or A549 cells were transiently transfected with a luciferase reporter gene construct driven by three copies of Oct-1 motif (pTK3XOct-1) or mutant Oct-1 motif at -10.2 kb (pTK3XMutOct-1) of hiNOS promoter. Luciferase activities were determined 1 day after transfection. (* indicates p<0.02 vs. empty vector. † indicates p<0.01 vs. pTK3XOct-1.)