Table 3.
Demographics of Patients and Donors for the Six Most Frequent HLA-A Disparities in HLA-B, -C, and -DRB1 Matched Pairs
| Variable | A*0201- A*0205 N (%) |
A*0301- A*0302 N (%) |
A*0201- A*0206 N (%) |
A*0201- A*6801 N (%) |
A*0101- A*1101 N (%) |
A*0101- A*0201 N (%) |
|---|---|---|---|---|---|---|
| Patients (n) | 28 | 15 | 15 | 12 | 11 | 10 |
| Centers (n) | 22 | 12 | 13 | 9 | 7 | 8 |
| Patient Age | ||||||
| Median (y) | 27 | 37 | 23 | 32 | 42 | 29 |
| Range (y) | 1-51 | 9-58 | 3-51 | 1-54 | 2-50 | 13-45 |
| < 20 y | 7 (25) | 1 (6) | 7 (46) | 4 (34) | 2 (18) | 4 (40) |
| 20-39 y | 14 (50) | 7 (47) | 4 (27) | 4 (33) | 3 (27) | 5 (50) |
| 40+ y | 7 (25) | 7 (47) | 4 (27) | 4 (33) | 6 (55) | 1 (10) |
| Male sex | 14 (50) | 7 (47) | 10 (67) | 7 (58) | 4 (36) | 7 (70) |
| Karnofsky ≥ 90 | 21 (78) | 12 (80) | 12 (80) | 8 (73) | 7 (64) | 9 (90) |
| Disease | ||||||
| AML | 7 (25) | 1 (7) | 5 (33) | 5 (42) | 3 (27) | 4 (40) |
| ALL | 10 (36) | 1 (7) | 3 (20) | 1 (8) | 0 | 0 |
| CML | 6 (21) | 11 (73) | 7 (47) | 3 (25) | 6 (55) | 4 (40) |
| MDS | 4 (14) | 2 (13) | 0 | 2 (17) | 2 (18) | 2 (20) |
| NHL | 1 (4) | 0 | 0 | 1 (8) | 0 | 0 |
| Disease status | ||||||
| Early | 7 (25) | 9 (60) | 6 (40) | 4 (33) | 4 (36) | 6 (60) |
| Intermediate | 11 (39) | 4 (27) | 9 (60) | 5 (42) | 4 (36) | 2 (20) |
| Advanced | 8 (29) | 2 (13) | 0 | 1 (8) | 1 (9) | 1 (10) |
| Other | 2 (7) | 0 | 0 | 2 (17) | 2 (18) | 1 (10) |
| Marrow | 28 (100) | 15 (100) | 15 (100) | 11 (92) | 10 (91) | 9 (90) |
| Conditioning | ||||||
| Ablative | 27 (96) | 14 (93) | 15 (100) | 12 (100) | 11 (100) | 10 (100) |
| Other | 1 (4) | 1 (7) | 0 | 0 | 0 | 0 |
| GvHD Prophylaxis | ||||||
| FK506 | 5 (18) | 2 (13) | 2 (13) | 4 (33) | 0 | 1 (10) |
| CsA | 17 (61) | 10 (67) | 13 (87) | 6 (51) | 10 (91) | 6 (60) |
| T-cell depletion | 6 (21) | 3 (20) | 0 | 1 ( 8) | 1 (9) | 3 (30) |
| Other | 0 | 0 | 0 | 1 ( 8) | 0 | 0 |
| Donor/recipient sex match |
||||||
| M/M | 10 (36) | 6 (40) | 7 (47) | 4 (33) | 2 (18) | 3 (30) |
| M/F | 10 (36) | 3 (20) | 3 (20) | 2 (17) | 5 (46) | 2 (20) |
| F/M | 4 (14) | 1 ( 7) | 3 (20) | 3 (25) | 2 (18) | 4 (40) |
| F/F | 4 (14) | 5 (33) | 2 (13) | 3 (25) | 2 (18) | 1 (10) |
| Donor/recipient CMV match |
||||||
| N/N | 14 (50) | 7 (47) | 2 (14) | 3 (25) | 5 (46) | 4 (40) |
| N/P | 6 (22) | 6 (40) | 3 (20) | 2 (17) | 3 (27) | 2 (20) |
| P/N | 4 (14) | 0 | 5 (33) | 1 ( 8) | 2 (18) | 3 (30) |
| P/P | 4 (14) | 2 (13) | 5 (33) | 5 (42) | 1 ( 9) | 0 |
| Unknown | 0 | 0 | 0 | 1 ( 8) | 0 | 1 (10) |
| Donor age (y) Median (range) |
40 (20-57) |
39 (21-50) |
36 (20-53) |
36 (29-47) |
39 (22-53) |
38 (22-49) |
| Year of transplant | ||||||
| 1990-1994 | 6 (21) | 3(20) | 3(20) | 1 ( 8) | 3(27) | 5(50) |
| 1995-2002 | 22(79) | 12(80) | 12(80) | 11(92) | 8(73) | 5(50) |
| Follow-up median mo (range) |
60 (48-101) |
111 (36-144) |
61 (22-99) |
77 (35-97) |
90 (60-157) |
55 (34-154) |