Table 4.
Transplant Outcomes for the Six Most Frequent HLA-A Disparities in HLA-B, -C, and -DRB1 Matched Pairs
| HLA Mismatch | A*0201: 0205 |
A*0301: 0302 |
A*0201: 0206 |
A*0201: 6801 |
A*0101: 1101 |
A*0101: 0201 |
|---|---|---|---|---|---|---|
|
Number of Amino Acid Differences |
4 | 2 | 1 | 12 | 11 | 24 |
|
Position and Single Letter Code for Amino Acid Differences |
9FY 43QR 95VL 156LW |
152EV 156LQ |
9FY | 9FY 62GR 63EN 66KN 70HQ 74HD 95VI 97RM 107WG 114HR 116YD 156LW |
9FY 44KR 67MV 70HQ 76AV 77ND 150VA 156RQ 158VA 166DE 167GW |
44KR 62QG 66NK 67MV 74DH 76AV 77ND 90DA 95IV 97IR 107GW 114RH 116 DY 127NK 142IT 145RH 150VA 152AV 156RL 158VA 163RT 105PS 166DE 167GW |
| N | 27* | 15 | 15 | 11* | 11 | 9* |
|
OR for Survival 95% CI |
2.08 0.86-4.80 (p=0.07) |
1.10 0.25-3.73 |
2.64 0.81-8.38 |
2.52 0.60-9.94 |
1.13 0.19-4.74 |
0.86 0.09-4.55 |
|
OR for Acute GvHD 95% CI |
1.41 0.55-3.33 |
1.03 0.24-3.48 |
3.22 1.02-10.50 (p=0.03) |
1.06 0.18-4.43 |
2.35 0.56-9.29 |
0.0 0.0-1.12 |
*
Three cases (1 A*0201:0205, 1 A*0201:6801 and 1 A*0101:0201) were not included in the multivariate analysis due to missing data.