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. 2003 Feb 10;88(3):420–423. doi: 10.1038/sj.bjc.6600733

Table 2. Mutations of Smad4 gene detected in colorectal cancer.

Patient Exon Alteration Effect
18 9 AGA→AGC Arginine (R)→Serine (S)
376 11 GCT→GTT Alanine (A)→Valine (V)

Two out of 73 patients (3%) with point mutations of Smad4.