Table 3. p53 mutations detected in this study; details of the histology of the patients bearing p53 mutations are included, along with details of the mutation itself (base change, amino-acid change).

Patient number	Histological stage	Mutations per biopsy	Mutated p53 condon	p53 mutation	Amino-acid change
2	HGD	1/2	1 at 248	cgg-cag	Arg-Gln
3	HGD	2/4	2 at 248	cgg-cag	Arg-Gln
4	HGD	7/8	7 at 248	cgg-cag	Arg-Gln
6	BM	2/5	2 at 248	cgg-cag	Arg-Gln
8	HGD	2/5	2 at 248	cgg-cag	Arg-Gln
12	BM	1/2	1 at 175	cgc-cac	Arg-His
13	LGD	2/6	1 at 175	cgc-tgc	Arg-Gln
			1 at 248	cgg-cag	Arg-Cys
18	BM	1/1	1 at 248	cgg-cag	Arg-Gln
26	LGD	2/2	2 at 282	cgg-cgt	No change
31	LGD	1/2	1 at 248	cgg-cag	Arg-Gln
33	BM	1/2	1 at 248	cgg-tgg	Arg-Trp
38	LGD	3/2	2 at 248	cgg-cag	Arg-Gln
			1 at 175	cgc-cac	Arg-His
42	HGD	1/1	1 at 248	cgg-tgg	Arg-Trp