Table 3. Comparison of the performance of PGA/PGC ratio as a diagnostic test to detect histological lesions acccording to gender and age. Results of the Eurohepygast study.

	Diagnosis of ACGa				Diagnosis of corpus or multifocal atrophy
	Global sample	Men	Women<41 years old	Women ⩾ 41 years old	Global sample
	n=289	n=117	n=70	n=102	n=289
Area under ROC curve	0.73	0.75	0.76	0.68	0.84
Cut-off point	5.6	5.6	6.4	5.6	4.7
Sensitivity (%)	65.1	64	75	69.2	77.1
95% CIb	52.7, 76.1	44.1, 80.8	45.9, 93.2	49.8, 84.6	61.2, 88.8
Specificity (%)	77.9	84.8	70.7	65.8	87.4
95% CIb	72.1, 82.9	76.3, 91.1	58.1, 81.3	54.6, 75.8	82.9, 91.1
PPVc (%)	45.1	53.3	34.6	40.9	45.8
95% CIb	35.1, 55.3	35.6, 70.5	18.4, 54.1	27.2, 55.8	33.4, 58.5
NPVd (%)	88.9	89.6	93.2	86.2	96.5
95% CIb	83.9, 92.7	81.9, 94.8	82.6, 98.2	75.5, 93.4	93.5, 98.4
Accuracy (%)	75.1	80	71.4	66.7	86.2

^aAtrophic chronic gastritis;

^b95% confidence interval;

^cpositive predictive value;

^dnegative predictive value.