TABLE 5.

Genotype-sex interactions for acute respiratory distress syndrome (ARDS) risk.

	All Subjects (n=1468)		Age <65 (n=736)		Age ≥65 (n=732)
Genotype-Sex Interaction	OR (95% CI)#	p-value ¶	OR (95% CI)#	p-value ¶	OR (95% CI)#	p-value ¶
rs4444903*sex	2.01 (1.18–3.43)	0.010+	2.50 (1.18–5.33)	0.017+	1.55 (0.72–3.33)	0.261
rs2298991*sex	2.02 (1.18–3.43)	0.010+	2.67 (1.26–5.69)	0.011+	1.44 (0.67–3.07)	0.350
rs11568893*sex	0.99 (0.52–1.89)	0.973	1.20 (0.49–2.96)	0.688	0.69 (0.26–1.85)	0.464
rs7692976*sex	2.07 (1.22–3.54)	0.007+	3.08 (1.45–6.57)	0.004+	1.32 (0.62–2.82)	0.473
rs4698803*sex	0.64 (0.37–1.09)	0.100	0.68 (0.32–1.48)	0.336	0.61 (0.28–1.30)	0.200
rs6533485*sex	1.96 (1.11–3.46)	0.021+	2.46 (1.09–5.56)	0.031+	1.46 (0.66–3.26)	0.353

OR: odds ratio; CI: confidence interval. Females with wildtype homozygote of each SNP were used as reference.

^#OR and 95% CI for interaction in multivariate logistic regression models, adjusted for age, sex, APACHE III score, all risk factors for ARDS (listed in table 1), diabetes, liver cirrhosis/failure and alcohol abuse. APACHE III score was revised to remove age from the score to avoid colinearity

^¶for interaction

⁺FDR adjusted p-value <0.05.