Figure 5.

Inhibitory effects of rac-Rh(DIP)2chrysi3+. Shown are plots of BrdU incorporation normalized to the BrdU incorporation of untreated cells as a function of rhodium concentration. Standard error bars for five trials are shown. MMR-proficient HCT116N cells (green) and MMR-deficient HCT116O cells (red) were plated and allowed 24 h to adhere before incubation with 0–5 μM rac-Rh(DIP)2chrysi3+ for 12 h. At the end of the incubation, the medium containing Rh was replaced with fresh medium, and cells were grown for an additional 60 h before ELISA analysis. BrdU was added to the medium 24 h prior to analysis.