Table 1. Summary of urine and blood analysis data for weeks 6 and 12 samples.

	6 Weeks		12 Weeks
Parameter	Control	Cd	Control	Cd
Urine volume (ml/kg/24 h)	34.3±2.2	47.3±5.0	18.8±1.5	148±14*
Urinary protein (mg/kg/24 h)	48.4±3.5	55.1±3.4	41.1±5.1	117±28*
Urinary creatinine (mg/kg/24 h)	27.5±1.6	24.5±2.4	28.7±1.7	30.2±1.2
Urinary glucose (mg/kg/24 h)	7.78±0.81	7.93±0.51	7.9±0.7	16.7±5.6
Urinary alkaline phosphatase (U/kg/24 h)	2.84±0.57	3.61±0.58	3.6±0.31	4.4±0.58
Urinary LDH (U/kg/24 h)	1.05±0.030	0.66±0.08	0.15±0.02	4.0±0.7*
Urinary albumin (mg/kg/24 h)	0.57±0.23	1.08±0.31	0.87±0.07	9.0±1.7*
Urine pH	8.41±0.3	8.0±0.03	7.2±0.3	9.0±0*
Urine specific gravity	1.006±0.003	1.006±0.002	1.010±0.002	1.000±0*
Serum creatinine (mg/dl)	0.45±0.05	0.48±0.05	0.92±0.03	1.3±0.16
BUN (mg/dl)	17.5±2.0	23.2±0.8*	27.6±1.8	43.0±2.8*

BUN, blood urea nitrogen; Cd, cadmium; LDH, lactate dehydrogenase.

Animals were treated with Cd (0.6 mg/kg, 5 days per week) for 6 or 12 weeks, and urine and blood samples were analyzed as described in the Materials and Methods section. The results for most of the urine analyses represent the mean±s.e.m. of 10-11 replicate samples for each treatment group. The values for serum creatinine and BUN represent the mean±s.e.m. for six controls and five Cd-treated animals. Since the Cd-treated animals gained significantly less weight than the control animals, the results of the urine analyses are expressed as units per kg body weight per 24 h.

^*An denotes significant differences from week matched control values as determined by two-tailed t-tests (P<0.05).