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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Curr Opin Pharmacol. 2009 Jun 29;9(4):462–469. doi: 10.1016/j.coph.2009.05.007

Figure 3. A schematic drawing illustrating the effects of recombinant HLA-G5 on resting and IFNγ-activated blood monocytes.

Figure 3

After 48 hr of incubation with HLA-G5 CD14+ cells that were resting (no IFNγ) demonstrated diminished synthesis of TNFα and IL-1 β in comparison with untreated cells but levels of IL-6 and the anti-inflammatory cytokine, IL-10, were unchanged. By contrast, when the cells were activated with 100 U/ml of IFNγ and simultaneously treated with recombinant HLA-G5 there were a modest increases in levels of TNFα and IL-1 β but a dramatic increase in the anti-inflammatory cytokine, IL-10. The data shown represent values obtained in one of three similar assays.