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. Author manuscript; available in PMC: 2009 Sep 21.
Published in final edited form as: Neuropsychopharmacology. 2007 May 9;33(4):769–782. doi: 10.1038/sj.npp.1301447

Figure 2.

Figure 2

Novelty- and cocaine-induced locomotor activity exhibited by PNS and control rats in distance (m) as measured by photobeam breaks. (a) Response to initial placement in a novel test environment in a 60-min test in control (n = 44 comprised three to eight rats from seven litters) and PNS (n = 46 comprised three to eight rats from nine litters) rats. (b) Response to vehicle injection (empty arrow) and cocaine injection (15 mg/kg i.p., filled arrow) in sequential 120 min tests in control (n = 12 comprised one to two rats from seven litters) and PNS rats (n = 12 comprised one to two rats from seven litters) without a history of cocaine-experience. Data shown as mean±SEM; symbol indicates a significant difference between the PNS and control rats (*p<0.05).