Table 1. DNA methylation probes with significant effects of age and gender (listed are genes for which significance was detected in both series independently).
| Range | Twins | Singletons | ||||||||||||
| Probe | min | max | B.x | Chi2.x | p.x | p.fdr.x | B.y | Chi2.y | p.y | p.fdr.y | Symbol | GenBank | Chr | Locus |
| Age | ||||||||||||||
| ACVR1_E328_R | 0.78 | 0.99 | −0.403 | 11.361 | 7.50E-04 | 3.88E-02 | −0.648 | 55.757 | 8.20E-14 | 2.30E-11 | ACVR1 | NM_001105.2 | 2 | 158402708 |
| IL6_E168_F | 0.00 | 0.32 | 0.476 | 18.525 | 1.68E-05 | 3.86E-03 | 0.443 | 37.288 | 1.02E-09 | 9.51E-08 | IL6 | NM_000600.1 | 7 | 22733513 |
| CARD15_P302_R | 0.17 | 0.61 | −0.390 | 11.309 | 7.71E-04 | 3.88E-02 | −0.440 | 33.265 | 8.04E-09 | 5.63E-07 | CARD15 | NM_022162.1 | 16 | 49288249 |
| PDGFRA_E125_F | 0.25 | 0.98 | 0.471 | 17.580 | 2.75E-05 | 3.86E-03 | 0.412 | 30.935 | 2.67E-08 | 1.29E-06 | PDGFRA | NM_006206.3 | 4 | 54790329 |
| NFKB1_P496_F | 0.08 | 0.50 | −0.422 | 15.125 | 1.01E-04 | 9.39E-03 | −0.361 | 30.863 | 2.77E-08 | 1.29E-06 | NFKB1 | NM_003998.2 | 4 | 103641022 |
| ELK3_P514_F | 0.01 | 0.28 | 0.385 | 11.172 | 8.30E-04 | 3.88E-02 | 0.380 | 28.501 | 9.37E-08 | 3.75E-06 | ELK3 | NM_005230.2 | 12 | 95111824 |
| Gender | ||||||||||||||
| TDGF1_P428_R | 0.22 | 0.64 | 0.791 | 10.777 | 1.03E-03 | 2.88E-02 | 1.050 | 41.315 | 1.30E-10 | 1.81E-08 | TDGF1 | NM_003212.1 | 3 | 46593789 |
| EVI2A_E420_F | 0.27 | 0.97 | 0.816 | 12.815 | 3.44E-04 | 1.60E-02 | 0.796 | 30.494 | 3.35E-08 | 2.34E-06 | EVI2A | NM_001003927.1 | 17 | 26672423 |
| NDN_E131_R | 0.54 | 0.87 | 1.028 | 23.063 | 1.57E-06 | 4.39E-04 | 0.487 | 26.130 | 3.19E-07 | 1.79E-05 | NDN | NM_002487.2 | 15 | 21483412 |
| PLAGL1_E68_R | 0.63 | 0.91 | 0.883 | 17.177 | 3.41E-05 | 4.77E-03 | 0.628 | 24.507 | 7.40E-07 | 3.46E-05 | PLAGL1 | NM_002656.2 | 6 | 144371178 |
| DNMT2_P199_F | 0.75 | 0.96 | 0.858 | 13.209 | 2.79E-04 | 1.56E-02 | 0.686 | 23.858 | 1.04E-06 | 4.15E-05 | DNMT2 | NM_004412.3 | 10 | 17283886 |
| ERN1_P809_R | 0.18 | 0.58 | −0.868 | 13.505 | 2.38E-04 | 1.56E-02 | −0.468 | 22.692 | 1.90E-06 | 6.66E-05 | ERN1 | NM_001433.2 | 17 | 59562017 |
| PTHR1_P258_F | 0.63 | 0.86 | 0.720 | 9.892 | 1.66E-03 | 3.87E-02 | 0.611 | 17.822 | 2.43E-05 | 6.17E-04 | PTHR1 | NM_000316.2 | 3 | 46893982 |
| XPC_P226_R | 0.75 | 0.99 | 0.904 | 14.454 | 1.44E-04 | 1.34E-02 | 0.553 | 20.202 | 6.97E-06 | 1.95E-04 | XPC | NM_004628.3 | 3 | 14195369 |
| PYCARD_P150_F | 0.18 | 0.48 | 0.756 | 11.670 | 6.35E-04 | 2.22E-02 | 0.263 | 10.500 | 1.19E-03 | 1.19E-02 | PYCARD | NM_145182.1 | 16 | 31121902 |
| SGCE_P250_R | 0.33 | 0.97 | 0.803 | 11.878 | 5.68E-04 | 2.22E-02 | 0.279 | 9.005 | 2.69E-03 | 1.98E-02 | SGCE | NM_003919.1 | 7 | 94123664 |