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. 2009 Oct;23(10):3415–3423. doi: 10.1096/fj.08-124602

Figure 4.

Figure 4.

Hsp27 inhibits IKKβ-induced MuRF1 promoter activation and disuse-induced MuRF1 and atrogin-1 mRNA expression. A) MuRF1 promoter reporter activity is increased following 3 d of immobilization, and overexpression of Hsp27 completely inhibits this activation. *P < 0.05 vs. weight-bearing control. B) Hsp27, but not IκBα SR, abolishes the increase in MuRF1 mRNA expression following 3 d of immobilization. *P < 0.05 vs. weight-bearing control. †P < 0.05 vs. immobilized control. C) WT IKKβ increases MuRF1 promoter activity, which is abolished in muscles coinjected with IKKβ and Hsp27. *P < 0.05 vs. control-injected muscles. †P < 0.05 vs. WT IKKβ-injected muscles. D) Hsp27, but not IκBα SR, attenuates the increase in atrogin-1 mRNA expression observed following 3 d of immobilization. *P < 0.05 vs. weight-bearing control. †P < 0.05 vs. immobilized control. Bars represent means ± se; ≥6 muscles/group.