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Permeabilization of the plasma membrane in oxidatively stressed cells requires the concerted action of PARP1 and PARG. Cells were exposed to indicated concentrations of hydrogen peroxide. Plasma membrane injury was assessed after 12 h by propidium iodide staining. Significant protection from oxidative stress was observed in shPARP1 and shPARG cells as compared to control. Data represent means ± sd of triplicate samples.
