Table 3. Haematologic toxicity.

	Leukopenia				Neutropenia				Anemia			Thrombocytopenia
Dose level	G1	G2	G3	G4	G1	G2	G3	G4	G1	G2	G3	G1	G2	G3	G4	Grade 3/4 toxicity (%)
Phase I
1 (n=3)	0	0	3	0	0	1	2	0	0	1	1	1	0	0	0	100
2 (n=3)	0	2	1	0	0	2	1	0	1	1	0	0	0	0	0	33
3 (n=2)	0	0	1	1	0	0	0	2	0	0	2	0	0	1	1	100
Phase II
2 (cycles=50)a	6	19	18	1	9	9	22	6	17	17	10	4	8	4	1	62a
1 (cycles=8)	0	2	5	1	0	1	3	4	1	2	5	1	2	2	1	100
Total (cycles=58)	6	21	23	2	9	10	25	10	18	19	15	5	10	6	2	67

^aThree patients were from the phase I study.