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Colonization of M. tuberculosis with various copies of mosR. (A) Lung colonization levels following aerosol infection with H37Rv, ΔmosR, ΔmosR::mosR, and Δcso strains. The asterisks denote significant differences in these times (Student's t test). The error bars indicate standard deviations. GM, gram. (B) Survival curves of mouse groups (n = 10) following aerosol infection with various strains of M. tuberculosis. The Δcso mutant was included as an example of a high inducer of PDIM.
