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. 2009 Jul 31;191(19):5976–5987. doi: 10.1128/JB.00465-09

FIG. 7.

FIG. 7.

Phylogeny of MrdH and related homologs. The neighbor-joining phylogram showed the clustering of MrdH and 35 other homologous proteins into three distinct subgroups. Bootstrap support values are indicated by percentages at the nodes. The accession codes of all of the homologs are indicated in the phylogenetic tree. The domain organizations of the corresponding subgroups are shown on the right side. RcnA proteins constituting subgroup 1 were found to be composed of a cyanobacterial marine plasmid hydrogenase domain (PD129330) and RcnA domains (PD031422 and PD031424). CEM proteins constituting subgroup 2 were predominantly composed of the cation efflux transporter system domain (PD001602), the cation efflux system domain found in CzcB homologs (PD036845), and the zinc transporter efflux cation system domain (PD001369). MrdH proteins constituting subgroup 3 exhibited chimeric domain organization derived from the RcnA domain (PD031422) and the cation efflux system domain found in CzcB homologs (PD036845).