FIG. 2.

Protein topology predictions. Five different topology prediction programs were used to identify membrane-spanning regions and cytoplasmic versus extracellular domains. The predictions shown are those produced by Phobius (18), which produced the matches most consistent with the majority of the other programs in each instance where differences were apparent. Hatched boxes indicate membrane-spanning helices, white boxes represent cytoplasmic domains, and black boxes indicate extracellular regions. B. canis, Brucella canis.