FIG. 6.

Induction of IL-10 (A) and IL-12p40 (B) secretion in MoDCs by M. bovis BCG. MoDCs were cocultured with mycobacteria for 24 h in the absence or presence of LPS, after which cytokine secretion was measured by ELISA. Shown are means of triplicates and the standard deviations of one representative experiment (five were conducted). IL-10 secretion by non-LPS-activated MoDCs upon infection with BCG was below the limit of detection (<20 pg ml⁻¹). ***, P < 0.0005; **, P < 0.005; *, P < 0.05 (compared to wild-type M. bovis BCG at equal MOIs).