FIG. 1.
Myc activation in intestinal epithelium elicits rapid morphological changes. Nontransgenic control (A) and villin-MycERTAM (B) mice were treated with tamoxifen (tam) for 3 days and dissected (C to F). Intestinal swelling is clearly evident following 3 days of Myc activation. Hematoxylin and eosin (H&E) analysis of villin-MycERTAM mice shows that Myc activation drives villi into a more crypt-like morphology. Regions boxed in panel F are magnified in panels G and H. (G) Yellow arrowheads show morphologically abnormal epithelial cells. (H) An example of epithelial overgrowth and detachment from the underlying stroma is detailed.