TABLE 2.

PRR and HR defects have opposite effects on the GCR rates of asf1 mutants

Relevant genotype	Wild type		asf1Δ
	Strain	Mutation rate,a Canr 5FOAr	Strain	Mutation rate,a Canr 5FOAr
Wild type	RDKY3615	3.5 × 10−10 (1)	RDKY4755	2.1 × 10−8 (62)
rad5Δ	RDKY5519	1.6 × 10−9 (5)	RDKY5753	3.3 × 10−9 (9)
rad6Δ	RDKY5516	2.8 × 10−9 (8)	RDKY5755	1.8 × 10−9 (5)
rad18Δ	RDKY5517	1.5 × 10−9 (4)	RDKY5757	2.0 × 10−9 (6)
bre1Δ	YKJM2233	<9.9 × 10−10 (3)b	RDKY5761	1.3 × 10−9 (4)
ubc13Δ	YKJM1585	1.3 × 10−9 (4)b	RDKY5884	2.4 × 10−9 (7)
mms2Δ	YKJM2135	<2.6 × 10−10 (1)b	RDKY5886	1.8 × 10−9 (5)
pol30-119	RDKY5873	8.3 × 10−10 (2)	RDKY5874	1.9 × 10−9 (6)
rad30Δ	RDKY5523	3.5 × 10−10 (1)c	RDKY5888	1.0 × 10−8 (30)
rev3Δ	RDKY5521	1.8 × 10−10 (0.5)c	RDKY5807	2.3 × 10−8 (65)
rad30Δ rev3Δ	RDKY6491	7.9 × 10−10 (2)	RDKY6493	1.1 × 10−8 (32)
siz1Δ	YKJM2179	1.3 × 10−9 (4)b	RDKY5759	3.2 × 10−9 (10)
srs2Δ	RDKY5028	<3.1 × 10−10 (1)	RDKY5890	1.44 × 10−9 (4)
rad51Δ	RDKY3636	3.5 × 10−9 (10)	RDKY4841	7.2 × 10−8 (205)
rad52Δ	RDKY4421	4.4 × 10−8 (126)	RDKY4855	4.4 × 10−7 (1,257)
rad59Δ	RDKY4423	7.5 × 10−9 (21)	RDKY4853	1.4 × 10−7 (400)

^aNumbers in parentheses indicate the increases (n-fold) in mutation rate compared to that for the wild type.

^bRate reprinted from reference 39.

^cRate determined by Meng-Er Huang in this laboratory (27).