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HAX-1 suppression by siRNA inhibits caspase-2 and -7 activation in 5-FU-treated HCV protein-expressing cells. Caspase-2 status after 5-FU treatment of parental HepG2, HepG2-core, or FL gene transfected cells in the presence or absence of siRNA to HAX-1 (A). Similar analyses were performed for caspase-7 using specific antibodies (B).
