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Comparison of rate constants of 4E10 binding to membrane-anchored and membrane-bound biepitope MPER peptide constructs
| Peptide-lipid conjugate | Encounter
|
Docking
|
Kd (nM) | ||
|---|---|---|---|---|---|
| ka (105M−1 s−1) | kd (10−2 s−1) | ka (10−3 s−1) | kd (10−3 s−1) | ||
| Membrane bound | 1.9 | 6.6 | 0.6 | 3.4 | 20.0 |
| Membrane anchored | 1.0 | 4.7 | 11.1 | 0.5 | 19.4 |
