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Sequence analysis predicts a DUB in KSHV Orf64. Clustal W alignment of the amino-terminal 500 amino acid residues of KSHV Orf64 and homologs from EBV (BPLF1) and HSV-1 (UL36) reveal key conserved amino acids, shown in red. Red arrows indicate components of the putative catalytic core of the cysteine protease.
