FIG. 7.

HSV-1 infection of epidermis from Rac1 E-KO mice. (A) Newborn wild-type control and Rac1 E-KO mice are shown. (B) Epidermal lysates from wild-type control and Rac1 E-KO mice were resolved on SDS-PAGE gels (15%) and stained with mouse anti-Rac1, mouse anti-Cdc42, or mouse anti-RhoA antibody. (C) Epidermal sheets of wild-type control and Rac1 E-KO mice were infected for 3 h. Epidermal sections were fixed and H-E stained. (D) Infected epidermal sections were costained for keratin 14 (red) and ICP0 (green). Confocal projections and merged images are shown. The arrow points to infected cells in the outer root sheath. Bar, 50 μm.