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. 2009 Jul 15;83(19):10234–10244. doi: 10.1128/JVI.00921-09

FIG. 2.

FIG. 2.

CD8+ T-cell responses to Gag epitopes in the first 12 months of life in children not on ART. Gag optimal epitopes presented by HLA-B*57, -5801, and -8101 are shown for slow-progressor (A) and progressor (B) children with protective HLA-B alleles. (C) Gag optimal epitope responses in slow-progressor and progressor children without protective HLA-B alleles. Symbols represent the magnitudes of CD8+ T-cell responses measured by ELISPOT assay at different time points in the first 12 months of life for children who deferred ART or in the first 12 months of cessation of ART for children who received immediate short-term ART. The magnitudes of responses in panel C are median magnitudes of the response for all time points tested. A significant response was defined as a peptide-specific response of ≥100 SFC/million PBMC (see Materials and Methods).