TABLE 2.
Deduced Gag epitope sequences in the 16 mother-child pairs where the mother and/or child possessed one or more of the protective HLA-B alleles
| Child or mother no. | Variant in epitope sequence in allelea
|
|||
|---|---|---|---|---|
| B*5702/5703/5801 (AISPRTLNAW [Gag positions 146 to 155]) | B*5703 (KAFSPEVIPMF [Gag positions 162 to 172]) | B*8101 (TPQDLNTML [Gag positions 181 to 189]) | B*5702/5703/5801 (TSTLQEQIAW [Gag positions 240 to 249]) | |
| Children | ||||
| 001-C | A146S | ▪ | ||
| 114-C | A146P/I147L | T242N | ||
| 133-C | ▪ | |||
| 135-C | ▪ | |||
| 241-C | Q183S/T187S | |||
| 284-C | A146P | T242N | ||
| 349-C | A146P/I147L/S148G | I247L/A248D | ||
| 413-C | D184E | |||
| 433-C | ▪ | ▪ | ||
| 468-C | N153S | ▪ | T242N | |
| 559-C | ▪ | I247V | ||
| 562-C | A146P | ▪ | ||
| 568-C | A146S/I147 M | L185 M/T187S | ||
| 579-C | A146P/I147L | ▪ | T242N | |
| 586-C | A146S | V168I | ▪ | A248G |
| 600-C | A146C/I147L | ▪ | ||
| Mothers | ||||
| 001-M | A146P | ▪ | ||
| 114-M | A146P/I147L | T242N/A248T | ||
| 133-M | ||||
| 135-M | ▪ | |||
| 241-M | Q183S/T187S | A248T | ||
| 284-M | A146P | T242N | ||
| 349-M | A146P/I147L/S148G | I247L/A248D | ||
| 413-M | I147L | Q183S | ||
| 433-M | ||||
| 468-M | ▪ | T242N | ||
| 559-M | T187 M | I247V | ||
| 562-M | ||||
| 568-M | A146S/I147 M | A163G | Q183S/T187S | |
| 579-M | A146P/I147L | ▪ | T242N | |
| 586-M | A146S | V168I | ||
| 600-M | A146C/I147L | |||
a
Data in bold and filled squares indicate that the mother or child possessed an HLA-B allele presenting the epitope; underlined data indicate that the mother but not the child possessed an HLA-B allele presenting the epitope.