FIG. 2.

Survival of wt and cathepsin-deficient mice following peroral inoculation. C57BL/6 wt and cathepsin-deficient mice, 2 to 4 days (d) old, were inoculated perorally with 10⁷ PFU T3SA+. Mice (n = 14 to 21) were monitored for survival (A) and weight gain (B). (A) *, P values of <0.01, as determined by a log rank test, in comparison to the wt level. (B) Results are expressed as mean weight of all living infected animals. Statistical significance (P values of <0.05 as determined by Student's t test) in comparison to the level for wt mice was achieved for Ctsb^−/− mice between days 2 and 8; for Ctsl^−/− mice at days 1, 13, and 14; and for Ctss^−/− mice at days 4 to 8, 11, and 14.