FIG. 3.

Reovirus titers in organs of wt and cathepsin-deficient mice following peroral inoculation. C57BL/6 wt and Ctsb^−/− (A), Ctsl^−/− (B), and Ctss^−/− (C) mice, 2 to 4 days (d) old, were inoculated perorally with 10² PFU T3SA+. Organs were resected at the times shown and homogenized by freeze-thawing and sonication. Viral titers in organ homogenates were determined by a plaque assay. Results are presented as mean viral titers in whole organs of 6 to 20 mice. Error bars represent standard errors of the means. *, P values of <0.05, as determined by a Mann-Whitney test, in comparison to the level for wt mice at the same time after inoculation. The limit of detection was 10² PFU/organ.