TABLE 1.

Mean survival time following reovirus infection^a

Genotype	No. of mice	Mortality (%)b	Mean survival time (days)c	Pd
wt	21	38.1	9.0 ± 1.2
Ctsb−/−	17	17.6	18.3 ± 0.9	0.0017
Ctsl−/−	15	93.3	12.6 ± 0.5	0.0041
Ctss−/−	13	61.5	13.3 ± 0.7	0.0098

^aC57/Bl6 wt and cathepsin-deficient mice, 2 to 4 days old, were inoculated perorally with 10⁷ PFU T3SA+. Mice were monitored for survival for 21 days.

^bPercent animals dead after 21 days.

^cMean survival time, as defined by the average day of death for animals that succumbed to infection, in number of days ± standard error of the mean.

^dP value, as determined by Student's t test, in comparison to the level for wt mice.