TABLE 2.
Bilirubin and liver enzyme levels in sera following reovirus infectiona
| Genotype | Concn in sera of indicated mouse group
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Mock infected
|
Reovirus infected
|
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| TBIL (mg/dl) | ALK (U/liter) | ALT (U/liter) | AST (U/liter) | TBIL (mg/dl) | ALK (U/liter) | ALT (U/liter) | AST (U/liter) | |
| wt | 1.5 | 634 | 127 | 461 | 0.9 (0.3) | 768 (140.8) | 295 (224.8) | 495 (231.2) |
| Ctsb−/− | 2.0 | 475 | 73 | 417 | 1.9 (0.2) | 783 (109.0) | 97.5 (31.1) | 460.5 (105.1) |
| Ctsl−/− | 1.5 | 567 | 57 | 409 | 9.2* (1.1) | 1282.4 (300.3) | 60 (20.8) | 439 (43.8) |
| Ctss−/− | 0.9 | 574 | 99 | 330 | 6.9* (2.0) | 1709* (258.9) | 858 (665.5) | 2083.75 (856.8) |
a
C57/Bl6 wt and cathepsin-deficient mice, 2 to 4 days old, were inoculated perorally with PBS alone or 106 PFU T3SA+. At day 12 postinoculation, the liver was resected and blood was collected. A small wedge of liver was removed for titer determination by a plaque assay. Mean values from two mock-infected mice or three to five reovirus-infected mice with approximately equivalent viral titers in the liver are shown. *, P values of <0.05, as determined by Student's t test, in comparison to the level for wt mice. The standard errors of the means are shown in parentheses.