TABLE 3.

Reovirus pathogenesis in cathepsin-deficient mice

Genotype	Survival rate	AST level	Level in mice inoculated perorally					Level of replication in brain in mice inoculated intracranially
			Replication in intestine	Replication in liver	Replication in heart	Replication in brain	Viremia
Ctsb−/−b	↑	↑	⇆	⇆	↓	↓	⇆	⇆
Ctsl−/−b	↓	↑	↓	↓	↓	↓	⇆	↓
Ctss−/−b	↓	↑	↓	↓	↓	↓	⇆	⇆
wt plus CLIK-148c	↑	ND	⇆	↓	↓	↓	ND	ND

^a↑, increase; ↓, decrease; ⇆, no change; ND, not determined.

^bResults shown are in comparison to the level for wt mice.

^cResults shown are in comparison to the level for wt mice treated with DMSO.