Table 1.
Estimated odds ratios and tests of association for rs4973768 and rs6504950
| Marker (chromosome, position) | Allelesa | Stage (cases/controls) | MAFb | Per-allele OR (95% CI)c | Heterozygote OR (95% CI)d | Homozygote OR (95% CI)e | P trend |
|---|---|---|---|---|---|---|---|
| rs4973768 (3p24, 27391017) | Stage 1 (388/355) | 0.46 | 1.33 (1.07–1.64) | 1.45 (1.01–2.07) | 1.76 (1.15–2.68) | 0.0087 | |
| C/T | Stage 2 (3,951/3,870) | 0.47 | 1.06 (0.99–1.03) | 0.99 (0.89–1.10) | 1.13 (0.99–1.28) | 0.081 | |
| Stage 3 (3,872/3,925) | 0.48 | 1.13 (1.06–1.20) | 1.03 (0.93–1.15) | 1.27 (1.12–1.44) | 0.00025 | ||
| Stage 4 (30,256/34,063) | 0.46 (0.21) | 1.11 (1.08–1.13) | 1.12 (1.08–1.17) | 1.23 (1.17–1.29) | 1.4 × 10−18 | ||
| Combined | 4.1 × 10−23 | ||||||
| rs6504950 (17q23, 50411470) | G/A | Stage 1 (390/357) | 0.31 | 0.76 (0.61–0.96) | 0.83 (0.61–1.13) | 0.52 (0.31–0.89) | 0.018 |
| Stage 2 (3,976/3,894) | 0.29 | 0.90 (0.84–0.96) | 0.86 (0.78–0.94) | 0.86 (0.73–1.02) | 0.0020 | ||
| Stage 3 (3,870/3,923) | 0.28 | 0.91 (0.85–0.98) | 0.89 (0.81–0.97) | 0.88 (0.73–1.04) | 0.012 | ||
| Stage 4 (30,470/33,302) | 0.27 (0.08) | 0.95 (0.92–0.97) | 0.96 (0.92–0.99) | 0.89 (0.83–0.95) | 0.00010 | ||
| Combined | 1.4 × 10−8 |
a
Major/minor allele (+ strand), based on the allele frequency in Europeans.
b
Minor allele frequency in Europeans (minor allele frequency in Southeast Asians in stage 4 shown in brackets).
c
Odds ratios (OR) per copy of the minor allele.
d
OR for heterozygotes relative to homozygotes for the common allele.
e
OR for homozygotes for the rare allele, relative to homozygotes for the common allele.