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Mean (SEM) for Aβ load (mm3) in hippocampal formation (HF) and neocortex (NTX) in dtg APPSWE/PS1ΔE9 mice. Treatment with 40% CR led to amyloid load reductions in NTX (p<0.05) and HF (p<0.057) compared to AL diet; % decrease = [(AL-CR)/AL].