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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Cell Immunol. 2009 Jul 10;259(2):177–184. doi: 10.1016/j.cellimm.2009.06.013

Figure 4. After sensitization and challenge, anti-CD28 significantly increased serum IgE and antigen-specific IgG1 in ICOS−/− mice.

Figure 4

Serum IgE or SEA specific IgG1 was measured on day 11 after sensitization and challenge with S. mansoni. A, Serum IgE from CD28+/+ mice (n=12) or CD28−/− mice injected i.p. every other day with HuFc (n=15) or B7RP-1-Fc (n=13). B, C, Serum IgE (B) and SEA specific IgG1 (C) from ICOS+/+ (n=3 each condition) or ICOS−/− mice (n=9 each condition) treated i.p. with 100μg anti-CD28 or PBS once at the time of sensitization.