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. 2009 Jun 24;29(25):8236–8247. doi: 10.1523/JNEUROSCI.1805-09.2009

Figure 5.

Figure 5.

PA suppresses degeneration in a Drosophila model of SBMA in a dFOXO-dependent manner. Right panel of each diptych shows higher magnification of the posterior margin of the eye, in which degeneration is concentrated. a, Flies expressing polyglutamine-expanded human androgen receptor (GMR, AR52Q) show degeneration when reared on food containing 1 mm dihydrotestosterone (+DHT). b, This degeneration is suppressed when food is supplemented with 0.5 mm PA. c, d, PA fails to rescue AR52Q-mediated degeneration in a dFOXO-deficient background. Bar graph below, Quantification of the degenerative eye phenotype (scored according to Pandey et al., 2007) shows that the neuroprotective effect of PA is lost when flies are haploinsufficient for dFOXO. Numbers of eyes scored are as follows: GMR, AR52: DMSO, n = 34, PA, n = 41; GMR, AR52; foxoBG01018: DMSO, n = 37, PA, n = 47; GMR, AR52; foxo21: DMSO, n = 20, PA, n = 16; GMR, AR52; foxo25: DMSO, n = 8, PA, n = 14; GMR, AR52; foxoC01841: DMSO, n = 28, PA, n = 20. Mean values are indicated with SE. p value was determined using Student's t test. *p < 0.05.