Table 2.

Characteristics of previously reported cases of estrogen-induced myelotoxicity in bitches

Reference	Breed	Age (y)	Reproductive status	BW (kg)	Drug/Dose	Route, Frequency	Reason for use
6	Cross-bred shepherd	6	intact	57	ECP/10 mg	IM, once	mismating
6	St. Bernard	4	intact	NS	a) ECP/10 mg	a) IM, 2 times 1 wk apart	infertility
					b) DES/90 mg	b) 50 mg, IM once + 5 mg PO, q24h for 8 d
8	NS	NS	NS	NS	ECP/0.22 mg/kg	IM 2 times at 21 d interval	urinary
8	NS	NS	NS	NS	ECP/0.08 mg/kg	IM 2 times at 15 d interval	urinary incontinence
8	NS	NS	NS	NS	NS	IM once	mismating
9	Airdale terrier	4	intact	20	ECP/2 mg	IM 3 times at 48- to 72-hour interval	mismating
10	Old English sheepdog	6	spayed	28	a) DES/18 μg/kg	a) PO, q24h for 15 mo	urinary incontinence
					b) DES/36 μg/kg	b) PO, q12h for 3 wk
					c) ECP/0.14 mg/kg	c) IM 2 times at 1 wk intervals
11	Glen of Imaal terrier	2	intact	NS	EB/10 μg/kg	SC 3 times at 2–3 d intervals	mismating
20	Poodle	2	intact	3.6	ECP/1 mg	IM 2 times at 1 wk intervals	mismating

NS — not specified, ECP — estradiol cypionate, DES — diethyl stilbesterol, EB — estradiol benzoate, IM — intramuscular, SC — subcutaneous, PO — per os.