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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: J Am Chem Soc. 2008 Sep 18;130(41):13552–13554. doi: 10.1021/ja8055358

Table 3.

Screen of Ligands for the Arylation of Methylaminea

graphic file with name nihms110657t3.jpg
Entry Precat Yieldb Temp MeN(H)Ar : MeNAr2c
1 6 92% rt >97:3
2 7 0% rt --
3 7 11% 80 °C 20:80
4 8 70% rt 82:18
a

ArCl (1 mmol), 2M MeNH2 in THF (2.0 mmol), Pd [6, 7, or 8] (1 mol %),15 NaOt-Bu (1.2 mmol).

b

GC yields.

c

Selectivities determined by GC.