. Author manuscript; available in PMC: 2009 Sep 22.

Published in final edited form as: Obesity (Silver Spring). 2008 Apr 10;16(6):1355–1362. doi: 10.1038/oby.2008.201

Table 4. Change in body composition, insulin sensitivity and markers of liver function and inflammation with caloric restriction.

	CR		CR+EX		LCD		CO
Value	Baseline	%Chg	Baseline	%Chg	Baseline	%Chg	Baseline	%Chg
Weight^a (kg) (22)	80.9 ± 114	-10 ± 3^*	82.3 ± 10.9	-10 ± 3^*	82.4 ± 11.3	-14 ± 2^*	81.7 ± 8.9	0 ± 4
Insulin sensitivity S_I (10^-4 mU/l/min)^a (24)	3.3 ± 1.7	40 ± 66^*	3.4 ± 1.3	79 ± 64^*	3.3 ± 1.7	83 ± 106^*	2.8 ± 1.2	1 ± 35
Body fat^a (%) (28)	30.9 ± 8.3	-15 ± 9^*	33.1 ± 7.8	-17 ± 8^*	32.7 ± 8.3	-21 ± 11^*	32.2 ± 6.6	-1 ± 6
TAT^a (kg) (22)	11.1 ± 2.2	-27 ± 12^*	11.2 ± 2.5	-30 ± 9^*	11.0 ± 3.2	-35 ± 10^*	11.0 ± 2.6	0 ± 10
SAT^a (kg) (22)	7.8 ± 2.4	-26 ± 13^*	8.5 ± 2.7	-30 ± 9^*	8.3 ± 2.7	-34 ± 9^*	8.1 ± 2.2	1 ± 10
VAT^a (kg) (22)	3.2 ± 1.8	-28 ± 12^*	2.6 ± 1.5	-28 ± 10^*	2.8 ± 1.5	-36 ± 10^*	3.0 ± 1.3	-2 ± 13
ALT (U/l)	23.8 ± 13.0	-28 ± 19^*	19.6 ± 9.7	-24 ± 24^*	17.2 ± 5.3	-2 ± 23	20.0 ± 9.1	-12 ± 11^*
ALK (U/l)	65.5 ± 20.2	-9 ± 6^*	54.7 ± 9.6	-6 ± 15	50.8 ± 13.0	-10 ± 8^*	63.9 ± 18.1	-7 ± 14
TNF-α (pg/ml)	8.3 ± 7.1	88 ± 115	7.1 ± 6.4	62 ± 114	5.4 ± 3.4	51 ± 83	7.8 ± 4.9	49 ± 36
IL-6 (pg/ml)	69.0 ± 64.7	71 ± 144^*	134.6 ± 153.7	6 ± 31	46.1 ± 59.3	70 ± 170	145.8 ± 197.6	10 ± 50
hsCRP (mg/dl)	0.25 ± 0.26	29 ± 184	0.15 ± 0.09	-26 ± 52	0.46 ± 0.38	-50 ± 27^*	0.34 ± 0.28	-27 ± 28^*

Values are means ± s.d.

ALK, alkaline phosphatase; ALT, alanine aminotransferase; CO, control; CR, caloric restriction; CR+EX, caloric restriction and increased structured exercise; hsCRP, high-sensitivity C-reactive protein; IL-6, interleukin-6; LCD, low-calorie diet; SAT, subcutaneous abdominal adipose tissue; TAT, total abdominal adipose tissue; TNF-α, tumor necrosis factor-α; VAT, visceral abdominal adipose tissue.

Data previously published in cited reference.

P < 0.05 vs. baseline.